Voluptuary habits and clinical subtypes of Parkinson's disease: The FRAGAMP case–control study
Identifieur interne : 000273 ( Main/Corpus ); précédent : 000272; suivant : 000274Voluptuary habits and clinical subtypes of Parkinson's disease: The FRAGAMP case–control study
Auteurs : Alessandra Nicoletti ; Pierfrancesco Pugliese ; Giuseppe Nicoletti ; Gennarina Arabia ; Grazia Annesi ; Michele De Mari ; Paolo Lamberti ; Lucia Grasso ; Roberto Marconi ; Antonio Epifanio ; Letterio Morgante ; Autilia Cozzolino ; Paolo Barone ; Giusi Torchia ; Aldo Quattrone ; Mario ZappiaSource :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
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Abstract
We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case–control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor‐Dominant (TD) and Akinetic‐Rigid (AR) patients. Four hundred ninety‐two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36–0.72), coffee drinking (OR 0.61; 95%CI 0.43–0.87) and wine consumption (OR 0.62; 95%CI 0.44–0.86); a significant trend dose‐effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose‐effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23297
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Italy</mods:affiliation></affiliation></author><author><name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name><affiliation><mods:affiliation>Clinica Neurologica, Università “Magna Græcia” di Catanzaro, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Mari, Michele De" sort="Mari, Michele De" uniqKey="Mari M" first="Michele De" last="Mari">Michele De Mari</name><affiliation><mods:affiliation>Clinica Neurologica, Università di Bari, Bari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name><affiliation><mods:affiliation>Clinica Neurologica, Università di Bari, Bari, Italy</mods:affiliation></affiliation></author><author><name sortKey="Grasso, Lucia" sort="Grasso, Lucia" uniqKey="Grasso L" first="Lucia" last="Grasso">Lucia Grasso</name><affiliation><mods:affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name><affiliation><mods:affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Epifanio, Antonio" sort="Epifanio, Antonio" uniqKey="Epifanio A" first="Antonio" last="Epifanio">Antonio Epifanio</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Torchia, Giusi" sort="Torchia, Giusi" uniqKey="Torchia G" first="Giusi" last="Torchia">Giusi Torchia</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Clinica Neurologica, Università “Magna Græcia” di Catanzaro, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Università di Catania, Catania, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30">2010-10-30</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2387">2387</biblScope><biblScope unit="page" to="2394">2394</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">116CA31DEBB29F1275F76E52B76521A6C756CB94</idno><idno type="DOI">10.1002/mds.23297</idno><idno type="ArticleID">MDS23297</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>alcohol</term><term>coffee</term><term>epidemiology</term><term>smoking</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case–control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor‐Dominant (TD) and Akinetic‐Rigid (AR) patients. Four hundred ninety‐two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36–0.72), coffee drinking (OR 0.61; 95%CI 0.43–0.87) and wine consumption (OR 0.62; 95%CI 0.44–0.86); a significant trend dose‐effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose‐effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype. © 2010 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Alessandra Nicoletti MSc</name><affiliations><json:string>Dipartimento di Neuroscienze, Università di Catania, Catania, Italy</json:string></affiliations></json:item><json:item><name>Pierfrancesco Pugliese MD</name><affiliations><json:string>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Giuseppe Nicoletti MD</name><affiliations><json:string>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Gennarina Arabia MSc</name><affiliations><json:string>Clinica Neurologica, Università “Magna Græcia” di Catanzaro, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Grazia Annesi PhD</name><affiliations><json:string>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Michele De Mari MD</name><affiliations><json:string>Clinica Neurologica, Università di Bari, Bari, Italy</json:string></affiliations></json:item><json:item><name>Paolo Lamberti MD</name><affiliations><json:string>Clinica Neurologica, Università di Bari, Bari, Italy</json:string></affiliations></json:item><json:item><name>Lucia Grasso LLD</name><affiliations><json:string>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</json:string></affiliations></json:item><json:item><name>Roberto Marconi MD</name><affiliations><json:string>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</json:string></affiliations></json:item><json:item><name>Antonio Epifanio MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</json:string></affiliations></json:item><json:item><name>Letterio Morgante MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</json:string></affiliations></json:item><json:item><name>Autilia Cozzolino MD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</json:string></affiliations></json:item><json:item><name>Paolo Barone MD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</json:string></affiliations></json:item><json:item><name>Giusi Torchia TNFP</name><affiliations><json:string>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Aldo Quattrone MD</name><affiliations><json:string>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</json:string><json:string>Clinica Neurologica, Università “Magna Græcia” di Catanzaro, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Mario Zappia MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Università di Catania, Catania, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>coffee</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>smoking</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>alcohol</value></json:item></subject><articleId><json:string>MDS23297</json:string></articleId><language><json:string>eng</json:string></language><abstract>We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case–control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor‐Dominant (TD) and Akinetic‐Rigid (AR) patients. Four hundred ninety‐two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36–0.72), coffee drinking (OR 0.61; 95%CI 0.43–0.87) and wine consumption (OR 0.62; 95%CI 0.44–0.86); a significant trend dose‐effect (P > 0.05) has been found for all the factors studied. We have also found a trend dose‐effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. 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study</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Voluptuary habits and clinical subtypes of Parkinson's disease: The FRAGAMP case–control study</title><author><persName><forename type="first">Alessandra</forename><surname>Nicoletti</surname></persName><roleName type="degree">MSc</roleName><affiliation>Dipartimento di Neuroscienze, Università di Catania, Catania, Italy</affiliation></author><author><persName><forename type="first">Pierfrancesco</forename><surname>Pugliese</surname></persName><roleName type="degree">MD</roleName><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation></author><author><persName><forename type="first">Giuseppe</forename><surname>Nicoletti</surname></persName><roleName type="degree">MD</roleName><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation></author><author><persName><forename type="first">Gennarina</forename><surname>Arabia</surname></persName><roleName type="degree">MSc</roleName><affiliation>Clinica Neurologica, Università “Magna Græcia” di Catanzaro, Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Grazia</forename><surname>Annesi</surname></persName><roleName type="degree">PhD</roleName><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation></author><author><persName><forename type="first">Michele De</forename><surname>Mari</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinica Neurologica, Università di Bari, Bari, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Lamberti</surname></persName><roleName type="degree">MD</roleName><affiliation>Clinica Neurologica, Università di Bari, Bari, Italy</affiliation></author><author><persName><forename type="first">Lucia</forename><surname>Grasso</surname></persName><roleName type="degree">LLD</roleName><affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</affiliation></author><author><persName><forename type="first">Roberto</forename><surname>Marconi</surname></persName><roleName type="degree">MD</roleName><affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</affiliation></author><author><persName><forename type="first">Antonio</forename><surname>Epifanio</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</affiliation></author><author><persName><forename type="first">Letterio</forename><surname>Morgante</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</affiliation></author><author><persName><forename type="first">Autilia</forename><surname>Cozzolino</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Barone</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</affiliation></author><author><persName><forename type="first">Giusi</forename><surname>Torchia</surname></persName><roleName type="degree">TNFP</roleName><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation></author><author><persName><forename type="first">Aldo</forename><surname>Quattrone</surname></persName><roleName type="degree">MD</roleName><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><affiliation>Clinica Neurologica, Università “Magna Græcia” di Catanzaro, Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Mario</forename><surname>Zappia</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Neurosciences, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy</p></note><affiliation>Dipartimento di Neuroscienze, Università di Catania, Catania, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2387">2387</biblScope><biblScope unit="page" to="2394">2394</biblScope></imprint></monogr><idno type="istex">116CA31DEBB29F1275F76E52B76521A6C756CB94</idno><idno type="DOI">10.1002/mds.23297</idno><idno type="ArticleID">MDS23297</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case–control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor‐Dominant (TD) and Akinetic‐Rigid (AR) patients. Four hundred ninety‐two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36–0.72), coffee drinking (OR 0.61; 95%CI 0.43–0.87) and wine consumption (OR 0.62; 95%CI 0.44–0.86); a significant trend dose‐effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose‐effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype. © 2010 Movement Disorder Society.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>epidemiology</term></item><item><term>coffee</term></item><item><term>smoking</term></item><item><term>alcohol</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-02-02">Received</change><change when="2010-05-03">Registration</change><change when="2010-10-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/116CA31DEBB29F1275F76E52B76521A6C756CB94/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="140"><doi origin="wiley" registered="yes">10.1002/mds.v25:14</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">14</numbering></numberingGroup><coverDate startDate="2010-10-30">30 October 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="180" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23297</doi><idGroup><id type="unit" value="MDS23297"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2010-02-02"></event><event type="manuscriptRevised" date="2010-04-20"></event><event type="manuscriptAccepted" date="2010-05-03"></event><event type="firstOnline" date="2010-07-28"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-07-28"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText source:FullText result:FullText" date="2011-07-06"></event><event type="publishedOnlineFinalForm" date="2010-10-25"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2387</numbering><numbering type="pageLast">2394</numbering></numberingGroup><correspondenceTo>Department of Neurosciences, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23297.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="35"></count><count type="wordTotal" number="7231"></count></countGroup><titleGroup><title type="main" xml:lang="en">Voluptuary habits and clinical subtypes of Parkinson's disease: The FRAGAMP case–control study<link href="#fn2"></link></title><title type="short" xml:lang="en">Voluptuary Habits and Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alessandra</givenNames><familyName>Nicoletti</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Pierfrancesco</givenNames><familyName>Pugliese</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Giuseppe</givenNames><familyName>Nicoletti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Gennarina</givenNames><familyName>Arabia</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Grazia</givenNames><familyName>Annesi</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Michele De</givenNames><familyName>Mari</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Paolo</givenNames><familyName>Lamberti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Lucia</givenNames><familyName>Grasso</familyName><degrees>LLD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Roberto</givenNames><familyName>Marconi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Antonio</givenNames><familyName>Epifanio</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Letterio</givenNames><familyName>Morgante</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Autilia</givenNames><familyName>Cozzolino</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" 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Messina, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">epidemiology</keyword><keyword xml:id="kwd3">coffee</keyword><keyword xml:id="kwd4">smoking</keyword><keyword xml:id="kwd5">alcohol</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case–control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor‐Dominant (TD) and Akinetic‐Rigid (AR) patients. Four hundred ninety‐two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36–0.72), coffee drinking (OR 0.61; 95%CI 0.43–0.87) and wine consumption (OR 0.62; 95%CI 0.44–0.86); a significant trend dose‐effect (<i>P</i> < 0.05) has been found for all the factors studied. We have also found a trend dose‐effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype. © 2010 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Voluptuary habits and clinical subtypes of Parkinson's disease: The FRAGAMP case–control study</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Voluptuary Habits and Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Voluptuary habits and clinical subtypes of Parkinson's disease: The FRAGAMP case–control study</title></titleInfo><name type="personal"><namePart type="given">Alessandra</namePart><namePart type="family">Nicoletti</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Dipartimento di Neuroscienze, Università di Catania, Catania, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierfrancesco</namePart><namePart type="family">Pugliese</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Nicoletti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gennarina</namePart><namePart type="family">Arabia</namePart><namePart 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Neurologica, Università di Bari, Bari, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lucia</namePart><namePart type="family">Grasso</namePart><namePart type="termsOfAddress">LLD</namePart><affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberto</namePart><namePart type="family">Marconi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Epifanio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Letterio</namePart><namePart type="family">Morgante</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Autilia</namePart><namePart type="family">Cozzolino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università Federico II, Napoli, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giusi</namePart><namePart type="family">Torchia</namePart><namePart type="termsOfAddress">TNFP</namePart><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aldo</namePart><namePart type="family">Quattrone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza, Italy</affiliation><affiliation>Clinica Neurologica, Università “Magna Græcia” di Catanzaro, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mario</namePart><namePart type="family">Zappia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Università di Catania, Catania, Italy</affiliation><description>Correspondence: Department of Neurosciences, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-10-30</dateIssued><dateCaptured encoding="w3cdtf">2010-02-02</dateCaptured><dateValid encoding="w3cdtf">2010-05-03</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">35</extent><extent unit="words">7231</extent></physicalDescription><abstract lang="en">We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case–control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor‐Dominant (TD) and Akinetic‐Rigid (AR) patients. Four hundred ninety‐two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36–0.72), coffee drinking (OR 0.61; 95%CI 0.43–0.87) and wine consumption (OR 0.62; 95%CI 0.44–0.86); a significant trend dose‐effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose‐effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype. © 2010 Movement Disorder Society.</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>epidemiology</topic><topic>coffee</topic><topic>smoking</topic><topic>alcohol</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>14</number></detail><extent unit="pages"><start>2387</start><end>2394</end><total>8</total></extent></part></relatedItem><identifier type="istex">116CA31DEBB29F1275F76E52B76521A6C756CB94</identifier><identifier type="DOI">10.1002/mds.23297</identifier><identifier type="ArticleID">MDS23297</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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